A fresh set of 20 random questions is generated every time you open this page and every time you refresh it.For each of the following multiple choice questions, choose the most appropriate answer :
1. In the mutagenesis dominant lethal test, which of the following would be exposed to the test substance?
A. Pre-mating male
B. Pre-mating female
C. Post-mating male
D. Post-mating female (pregnant)
2. Unlike inhaled anesthetics, intravenous agents such as thiopental, etomidate, and propofol:
A. Have a faster onset and rate of recovery
B. Provide a state of conscious sedation
C. Are commonly used for induction of anesthesia
D. All of these
3. Patients who are in chronic pain should
A. stay in bed.
B. keep a pain diary.
C. avoid vacations.
D. None of these
4. Tardive dyskinesia is the result of:
A. Degeneration of dopaminergic and cholinergic fibers
B. Hyperactive dopaminergic state in the presence of dopamine blockers
C. Degeneration of histaminergic fibers
D. Supersensitivity of cholinergic receptors in the caudate-putamen
5. This is a drug of choice for acute treatment of ventricular tachycardias:
A. Flecainide
B. Sotalol
C. Lidocaine
D. Verapamil
6. Mechanism of Rifampin action is:
A. Inhibition of mycolic acids synthesis
B. Inhibition of DNA dependent RNA polymerase
C. Inhibition of topoisomerase II
D. Inhibition of cAMP synthesis
7. The symptoms resulting from the combination of disulfiram and alcohol are:
A. Hypertensive crisis leading to cerebral ischemia and edema
B. Nausea, vomiting
C. Respiratory depression and seizures
D. Acute psychotic reactions
8. Principal aim for treatment of Parkinsonian disorders is:
A. To restore the normal balance of cholinergic and dopaminergic influences on the basal ganglia with antimuscarinic drugs
B. To restore dopaminergic activity with levodopa and dopamine agonists
C. To decrease glutamatergic activity with glutamate antagonists
D. All of these
9. All of the following drugs are antiemetics EXCEPT:
A. Metoclopramide
B. Ondansetron
C. Chlorpromazine
D. Apomorphine hydrochloride
10. Which of the following occurs acutely, leading to a false neurotransmitter, with increased guanethidine? (sympathomimetic)
A. Stimulation of NE release
B. Inhibition of NE release
C. Stimulation of ACh release
D. Inhibition of ACh release
11. All these drug groups useful in angina both decrease myocardial oxygen requirement (by decreasing the determinations of oxygen deman and increase myocardial oxygen delivery (by reversing coronary arterial spasm), EXCEPT:
A. Nitrates and nitrite drugs (Nitroglycerin, Isosorbide dinitrate)
B. Calcium channel blockers (Nifedipine, Nimodipine)
C. Beta-adrenoceptor-blocking drugs (Atenolol, Metoprolol)
D. Potassium channel openers (Minoxidil)
12. Neuroleptics are used to treat:
A. Neurosis
B. Psychosis
C. Narcolepsy
D. Parkinsonian disorders
13. All of these drugs reduce intestinal peristalsis EXCEPT:
A. Loperamide
B. Cisapride
C. Methyl cellulose
D. Magnesium aluminium silicate
14. False about Antiepileptics is
A. Phenytoin and Carbamazepine act by prolongation of inactivated state of Na+ Channels
B. Diazepam is anti-epileptic
C. Carbamazepine used for Trigeminal Neuralgia
D. Lamotrigine acts by opening of GABA mediated Cl- channels
15. Which route of drug administration is most likely to lead to the first-pass effect?
A. Sublingualpharmagang.comthanks and give credit to original source for this compilation6
B. Oral
C. Intravenous
D. Intramuscular
16. Despite having short half-life, PPI acts longer because
A. Causes irreversible inhibition of proton pump. Acid secretion suppressed till new pumps are generated
B. Get trapped in canaliculi
C. Enteric coated tablets causing slow release
D. Prodrugs and needs generation of active metabolites
17. Which one of the following statements about the metabolism of local anesthetics is incorrect?
A. Metabolism of local anesthetics occurs at the site of administration
B. Metabolism occurs in the plasma or liver but not at the site of administration
C. Ester group of anesthetics like procaine, are metabolized systemically by pseudocholinesterase
D. Amides such as lidocaine, are metabolized in the liver by microsomal mixed function oxidases
18. Flumazenil is used to:
A. Reverse the CNS depressant effects of hypnotic benzodiazepines overdose
B. Hasten recovery following use of hypnotic benzodiazepines in anesthetic and diagnostic procedure
C. Reverse benzodiazepine-induced respiratory depression
D. All of these
19. Antimuscarinics are used in the treatment of the following disorders EXCEPT:
A. Motion sickness
B. Glaucoma
C. Hyperhidrosis
D. Asthma
20. Repeated administration of acetophenetidin has adverse effect upon :
A. A . Kidney
B. Liver
C. Eye sight
D. Hearing
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