A fresh set of 20 random questions is generated every time you open this page and every time you refresh it.For each of the following multiple choice questions, choose the most appropriate answer :
1. Which of the following cytokine receptors (transmembrane enzyme) is antagonized by anakinra (Kineret), for treatment of rheumatoid arthritis?
A. Growth hormone
B. Erythropoietin
C. Interferons
D. Interleukin-1
2. Which drugs may be used as antianxiety agents?
A. BETA-blocking drugs
B. Clonidine - a partial agonist of alfa2 receptors
C. Tricyclic antidepressants
D. All of these
3. When carbidopa and levodopa are given concomitantly:
A. Levodopa blood levels are increased, and drug half-life is lengthened
B. The dose of levodopa can be significantly reduced (by 75%), also reducing toxic side effects
C. A shorter latency period precedes the occurrence of beneficial effects
D. All of these
4. Mechanism of action of I.V. IgG preparation is:
A. Inhibits CD3 receptor
B. Inhibits calcineurin
C. Complement-mediated cytolysis of T lymphocytes
D. Compete for Fc receptors with autoantibodies
5. All of the following agents are the first-line antimycobacterial drugs, EXCEPT:
A. Rifampin
B. Pyrazinamide
C. Isoniazid
D. Streptomycin
6. Tick the antimalarial drug influencing tissue schisonts:
A. Mefloquine
B. Chloroquine
C. Quinidine
D. Primaquine
7. Indicate the location of M2 cholinoreceptor type:
A. Heart
B. Glands
C. Smooth muscle
D. Endothelium
8. Tick the unwanted effects of fluoroquinolones:
A. Hallucinations
B. Headache, dizziness, insomnia
C. Hypertension
D. Immunetoxicity
9. Actions of mifepristone (RU-486) include:
A. Inhibition of ovulation during the follicular phase by blocking hypothalamic-pituitary progesterone receptors, which suppresses midcycle gonadotropin release
B. During the luteal phase, inhibition of progesterone action on the uterus, which induces prostaglandin release from the endometrium
C. Termination of pregnancy by facilitating luteolysis, menstruation, uterine motility, softening of the cervix, and detachment of the embryo.
D. All of these
10. Which of the following drugs is useful for the treatment of advanced prostate cancer?
A. Ganirelix
B. Cetrorelix
C. Abarelix
D. Goserelin
11. Which of the following sympathomimetics is a beta2-selective agonist?
A. Terbutaline
B. Xylometazoline
C. Isoproterenol
D. Dobutamine
12. What part of the cholinergic synapse is affected by botulinum toxin?
A. ACh increased
B. ACh decreased
C. Muscarinic ACh receptor modified
D. Nicotinic ACh receptor modified
13. The principal central nervous system effect of the opioid analgesics with affinity for a mu receptor is:
A. Analgesia
B. Respiratory depression
C. Euphoria
D. All of these
14. Which synapses are involved in depression?
A. Dopaminergic synapses
B. Serotoninergic synapses
C. Cholinergic synapses
D. All of these
15. The non-glycoside positive inotropic drug is:
A. Digoxin
B. Strophantin K
C. Dobutamine
D. Digitoxin
16. What chemical mediators bring about the inflammatory reaction by vaso- dilatation, relaxing smooth muscles, making capillaries permeable, and sensitizing nerve cells within the affected area to pain?
A. PCN
B. Sulfonamides
C. Prostaglandins inhibitors
D. Prostaglandins
17. Narrow therapeutic index is seen with:
A. Desipamine
B. Lithium
C. Penicillin
D. Diazepam
18. A correct dose of medication for a pediatric patient is determined by
A. the patient’s weight.
B. the patient’s height.
C. the patient’s age.
D. the patient’s sex
19. Indicate the anesthetic agent of choice in patient with a liver disease:
A. Lidocaine
B. Bupivacaine
C. Procaine
D. Etidocaine
20. What clinical trial phase involves single- or double-blind studies under very controlled conditions with the purpose to determine therapeutic effect at tolerated doses?
A. Phase 1
B. Phase 2
C. Phase 3
D. Phase 4
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